Stem Cell Factor
Mesenchymal stem cells release a variety of bioactive factors through paracrine mechanisms, including growth factors such as EGF, VEGF, and FGF, as well as cytokines like IL and TNF, and chemokines. These factors help accelerate tissue repair and promote cellular activation.
Common factors in stem cells
Stem cell factors encompass over a hundred bioactive molecules, with the following being among the most common:
Epidermal Growth Factor (EGF):Promotes epidermal cell proliferation and accelerates skin barrier repair.
Fibroblast Growth Factor (FGF):Stimulates collagen and elastin synthesis, improving skin elasticity.
Vascular Endothelial Growth Factor (VEGF):Promotes angiogenesis, enhancing skin microcirculation and nutrient delivery.
Transforming Growth Factor-β (TGF-β):Inhibits matrix metalloproteinases (MMPs), reduces collagen degradation, and slows down wrinkle formation.
Keratinocyte Growth Factor (KGF):It promotes keratinocyte regeneration and helps repair the skin barrier; boosts the synthesis of moisturizing factors, leaving skin hydrated and plump; and also stimulates collagen and elastin fiber production, offering anti-aging and wrinkle-smoothing benefits.
Interleukin-10 (IL-10):Inhibit inflammatory responses and reduce redness in sensitive skin, as well as acne-related inflammation.
Tumor Necrosis Factor-α (TNF-α) Regulatory Factor:Balance the inflammatory microenvironment to reduce skin aging caused by chronic inflammation.
Fibronectin (FN1):Fibronectin generally promotes skin repair and enhances the skin's natural defenses.
Superoxide Dismutase (SOD-1):Superoxide dismutase in skincare products offers benefits such as delaying aging, combating lipid peroxidation, brightening skin, repairing skin damage, and reducing inflammation.
COL3A1 (Hyaluronic Acid):Hyaluronic acid offers moisturizing, anti-aging, UV protection, wound-healing, and antibacterial and anti-inflammatory benefits and effects.
ELN (Elastin):It can effectively improve vascular aging, enhance skin elasticity, and refine skin condition.
Platelet-Derived Growth Factor (PDGF-BB):Activates fibroblasts, stimulates Type I collagen synthesis, and directly improves skin laxity and wrinkles.
Matrix Cell-Derived Factor-1 (SDF-1):By enhancing the homing effect of epidermal stem cells via the CXCR4 receptor, skin barrier repair is accelerated.
Technological Advantages
Low activity loss, easy to store
A unique hypoxic culture process that mimics the body's natural microenvironment, reducing reactive oxygen species (ROS) accumulation and enhancing energy efficiency, thereby boosting the secretion of cytokines such as IL-10, VEGF, EGF, bFGF, and others.
Pharmaceutical-grade GMP-compliant, sterile, and stable
Jiuzhitang Maker has achieved large-scale cultivation of stem cells at its GMP-compliant production facility, maintaining robust stem cell properties even after 35 days of continuous culture. The resulting factor-based products are uniform and stable, perfectly meeting the requirements for developing both topical and medical-device-grade products.
Low activity loss, easy to store
The unique foam-drying technology eliminates the need for refrigeration and preserves the activity of critical proteins and factors throughout the product’s shelf life.
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