R&D achievements
The Jiuzhitang Maker research team has published two SCl articles: "A Comparative Study on the Effects of Different Doses of hBMMSC Transplantation via Intravenous Route in Improving Post-Stroke Neurological Outcomes," featured in the internationally renowned academic journal *Brain Research*, and "Intravenous Transplantation of Bone Marrow Mesenchymal Stem Cells Alleviates Behavioral Deficits and Modifies Gut Microbiota Composition in BTBR Mice," published in *Life Sciences*. The publication of Jiuzhitang Maker’s original research highlights the company’s significant achievements in advancing its scientific capabilities and strengthening its research team. Looking ahead, Jiuzhitang Maker is poised to continue making steady progress and innovation in the years to come.
Journal publication
This study used different doses of hBMMSC to act on MCAO rats and examined the effects of hBMMSC under different concentration gradients and time conditions. The results showed that hBMMSC treatment could significantly improve the sensory and motor function of stroke rats and reduce the volume of cerebral infarction. In addition, different doses of hBMMSCs all reflect their therapeutic effects on brain rate. The low-dose group, injected with 1x106 cells, showed significant therapeutic effects in terms of neurobehavioral recovery and stroke reduction. The inhibitory effect of medium and high doses of hBMMSCs on the activation of small stem cells is stronger. This result suggests that hBMMSC may be an effective treatment for ischemic stroke.
The study findings reveal that hBMMSC treatment significantly ameliorates social deficits in BTBR mice, as evidenced by improvements observed in the Open Field Test (OFT), Light-Dark Box Test (LBT), Novel Object Recognition (NOR), and Free Social Test (FST), while also markedly reducing stereotypical behaviors. Furthermore, hBMMSC administration effectively reversed the alterations in microbial community composition in BTBR mice, particularly restoring the balance between Firmicutes and Bacteroidetes. Notably, several specific taxonomic groups correlated with ASD prognosis and behavioral scores, suggesting that intravenous injection of hBMMSC exerts beneficial effects on ASD by not only alleviating social impairments but also modulating gut microbiota composition. These findings highlight nBMMSC intravenous transplantation as a promising therapeutic strategy for potentially improving ASD symptoms.
Jiuzhitang Maker continues to ramp up its investment in research and development, actively pursuing technological innovation. As a result, the company has achieved notable progress in areas such as driving technological upgrades, safeguarding its independent intellectual property rights, and strengthening its competitive edge in technology. To date, Jiuzhitang Maker has been granted 8 patents and holds 17 copyrights for computer software.
Patent Grant
Ultrafiltration System
A new type of single-use liquid dispensing bag
A dermatology-specific medication applicator
An injection device for ischemia-tolerant human bone marrow mesenchymal stem cells
A storage device for ischemia-tolerant human neural stem cells
A probe holder
A new type of liquid dispensing bag
A 3D cell-based culture device for human bone marrow mesenchymal stem cells
Software Copyright
Hypoxia-Responsive Stem Cell Preparation Platform V1.0
Stem Cell Traceability Management System V1.0
Stem Cell Bank Management System V1.0
Stem Cell Preparation Tissue Repair Capability Testing System V1.0
Neural Stem Cell Preparation and Production System V1.0
Cytokine Secretion Assay Platform V1.0
Stem Cell Light Inspection AI Recognition System V1.0
Stem Cell Storage Temperature and Humidity Control System V1.0
Stem Cell Filling Control System V1.0
Cell Product Culture and Testing System V1.0
Cell Product Release Control System V1.0
MDMS Document Management System V1.0
MELN Electronic Lab Notebook System V1.0
MLIMS Laboratory Information Management System V1.0
MMES Manufacturing Execution System V1.0
MQMS Quality Management System V1.0
MWMS Warehouse Management System V1.0
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